| E.V.O. Search for Eden |
| Earth Light |
| Earth Light - Luna Strike |
| Earthbound |
| Earthworm Jim |
| Earthworm Jim 2 |
| Edono Kiba |
| Eek! The Cat |
| Eien no Filena |
| Elfaria |
| Elfaria II - The Quest of the Meld |
| Elite Soccer |
| Elnard |
| Emerald Dragon |
| EMIT Vol.1 - Toki no Maigo |
| EMIT Vol.2 - Inochigake no Tabi |
| EMIT Vol.3 - Watashi ni Sayonara wo |
| Emmitt Smith Football |
| Energy Breaker |
| Equinox |
| Eric Cantona Football Challenge |
| Esparks - Ijikuu Kara no Raihousha |
| ESPN Baseball Tonight |
| ESPN National Hockey Night |
| ESPN Speedworld |
| ESPN Sunday Night NFL |
| Estpolis Denki |
| Estpolis Denki ll |
| Europa Sensen |
| Excitebike Bun Bun Mario Battle Stadium |
| Exertainment Mountain Bile Rally |
| Exhaust Heat |
| Exhaust Heat II - F-1 Driver no Kiseki |
| Extra Innings |
