| S.C.A.R.S. |
| Saikyou Habu Shougi |
| San Francisco Rush - Extreme Racing |
| San Francisco Rush 2049 |
| Scooby-Doo! - Classic Creep Capers |
| SD Hiryuu no Ken Densetsu |
| Shadow Man |
| Shadowgate 64 - Trials Of The Four Towers |
| Shigesato Itoi's No. 1 Bass Fishing! Definitive Edition |
| Shin Nihon Pro Wrestling - Toukon Road - Brave Spirits |
| Shin Nihon Pro Wrestling - Toukon Road 2 - The Next Generation |
| Sim City 2000 |
| Snobow Kids |
| Snow Speeder |
| Snowboard Kids |
| Snowboard Kids 2 |
| Sonic Wings Assault |
| South Park |
| South Park - Chef's Luv Shack |
| South Park Rally |
| Space Dynamites |
| Space Invaders |
| Space Station Silicon Valley |
| Spider-Man |
| Spiderman |
| Star Fox 64 |
| Star Soldier - Vanishing Earth |
| Star Twins |
| Star Wars - Rogue Squadron |
| Star Wars - Shadows of the Empire |
| Star Wars Episode I - Battle for Naboo |
| Star Wars Episode I - Racer |
| Star Wars: Shutsugeki! Rogue Chuutai |
| Star Wars: Teikoku no Kage |
| StarCraft 64 |
| Starshot - Space Circus Fever |
| Streets of Rage 4 |
| Stunt Racer 64 |
| Super B-Daman - Battle Phoenix 64 |
| Super Bowling |
| Super Bowling 64 |
| Super Mario 64 |
| Super Robot Spirits |
| Super Robot Taisen 64 |
| Super Smash Bros. |
| Supercross 2000 |
| Superman |
| Superman 64 |
| Superman: The New Superman Adventures |
| Susume! Taisen Puzzle Dama Toukon! Marumata Chou |
