| Sagaia |
| Saint Sword |
| Same! Same! Same! |
| Same! Same! Same! |
| Samurai Shodown |
| Samurai Spirits |
| Sangokushi II |
| Sangokushi III |
| Sangokushi Retsuden |
| Sangokushi Retsuden - Ransei no Eiyuu Tachi |
| Saturday Night Slam Masters |
| Scooby Doo Mystery |
| Scrabble |
| SeaQuest DSV |
| Second Samurai, The |
| Sega Channel |
| Sega HMD and Tracker Demo - OA7-TST |
| Sega Music Joystick Demo |
| Sega Radica! Volume 1 |
| Sega Radica! Volume 1 BIOS |
| Sega Sports 1 (Wimbledon, Ult.Soccer, Super Monaco) |
| Sega Subor System Cartridge |
| Sega Top 5 |
| SEGA Top Ten |
| Sega-CD BIOS |
| Sensible Soccer |
| Sensible Soccer - International Edition |
| Sesame Street Counting Cafe |
| Shadow Blasters |
| Shadow Dancer - The Secret of Shinobi |
| Shadow of the Beast |
| Shadow of the Beast 2 |
| Shadowrun |
| Shane Warne Cricket |
| Shanghai 2 - Dragon's Eye |
| Shaq Fu |
| Shi Kin Joh |
| Shin Changsegi - Ragnacenty |
| Shining and the Darkness |
| Shining Force |
| Shining Force - Kamigami no Isan |
| Shining Force - The Legacy of Great Intention |
| Shining Force II |
| Shining Force II - Inishie no Fuuin |
| Shining in the Darkness |
| Shinobi III - Return of the Ninja Master |
| Shiten Myooh |
| Shogi no Hoshi |
| Shove It! - The Warehouse Game |
| Show do Milhao |
| Show do Milhao Volume 2 |
| Shura no Mon |
| Side Pocket |
| Simpsons, The - Bart vs The Space Mutants |
| Simpsons, The - Bart's Nightmare |
| Skeleton Krew |
| Skitchin' |
| Slam Dunk - Shikyou Gekitotsu! |
| Slap Fight |
| Slaughter Sport |
| Smart Mouse |
| Smurfs 2, The |
| Smurfs, The |
| Snake Rattle 'n' Roll |
| Snow Bros. - Nick & Tom |
| Socket |
| Sokoban |
| Sol-Deace |
| Soldiers of Fortune |
| Soleil |
| Sonic 3D Blast |
| Sonic 3D: Flickies' Island |
| Sonic and Crackers |
| Sonic and Knuckles |
| Sonic and Knuckles & Sonic 1 |
| Sonic and Knuckles & Sonic 2 |
| Sonic and Knuckles & Sonic 3 |
| Sonic Classics (Compilation) |
| Sonic Eraser |
| Sonic Jam 6 |
| Sonic Jam 6 |
| Sonic Spinball |
| Sonic The Hedgehog |
| Sonic The Hedgehog 2 |
| Sonic The Hedgehog 3 |
| Sorcer Kingdom |
| Sorcerer's Kingdom |
| Sorcerian |
| Soul Blade |
| Space Funky B.O.B. |
| Space Harrier II |
| Space Invaders 90 |
| Space Invaders 91 |
| Sparkster - Rocketknight Adventures 2 |
| Speed Ball 2 - Brutal Deluxe |
| Spider-Man - The Animated Series |
| Spider-Man and Venom - Maximum Carnage |
| Spider-Man and Venom - Separation Anxiety |
| Spider-Man and X-Men - Arcade's Revenge |
| Spider-Man vs The Kingpin |
| Spiritual Warfare |
| Spirou |
| Splatterhouse 2 |
| Splatterhouse 3 |
| Splatterhouse Part 3 |
| Splatterhouse Part2 |
| Sport Games |
| Spot Goes to Hollywood |
| Squirrel King |
| Star Control |
| Star Cruiser |
| Star Odyssey |
| Star Trek - Deep Space 9 - Crossroads of Time |
| Star Trek - The Next Generation |
| Starflight |
| Stargate |
| Steel Empire, The |
| Steel Talons |
| Stormlord |
| Story of Thor, The - A Successor of The Light |
| Street Fighter II' - Special Champion Edition |
| Street Fighter II' Plus - Champion Edition |
| Street Racer |
| Street Smart |
| Streets of Rage |
| Streets of Rage 2 |
| Streets of Rage 3 |
| Strider |
| Strider Hiryuu |
| Strider II |
| Striker |
| Sub-Terrania |
| Summer Challenge |
| Sunset Riders |
| Super 15-in-1 |
| Super 19-in-1 |
| Super Airwolf |
| Super Baseball 2020 |
| Super Battle Tank - War in the Gulf |
| Super Battleship |
| Super Bubble Bobble |
| Super Chinese Tycoon |
| Super Daisenryaku |
| Super Donkey Kong 99 |
| Super Fantasy Zone |
| Super Hang-On |
| Super High Impact |
| Super HQ |
| Super Hydlide |
| Super Kick Off |
| Super King Kong 99 |
| Super League |
| Super League 91 |
| Super Mario 2 1998 |
| super mario bros |
| super mario bros |
| Super Mario Bros. |
| Super Mario Bros. 2 |
| Super Mario World |
| super mario world |
| Super Masters Golf |
| Super Monaco Grand Prix |
| Super Off Road |
| Super Real Basketball |
| Super Shinobi II, The |
| Super Skidmarks |
| Super Smash TV |
| Super Street Fighter II - The New Challengers |
| Super Thunder Blade |
| Super Volleyball |
| Superman |
| Surging Aura |
| Sword of Sodan |
| Sword of Vermilion |
| Syd of Valis |
| Sylvester & Tweety in Cagey Capers |
| Syndicate |
