| Safari Hunt |
| Safari Race |
| Sagaia |
| Sangokushi 3 |
| Sapo Xule: S.O.S. Lagoa Poluida |
| Satellite 7 |
| Scramble Spirits |
| Secret Command |
| Secret Commando |
| Sega BASIC |
| Sega Chess |
| Sega Disk Basic |
| Sega Galaga |
| Sega Logo V1.0e |
| Sega Music Editor |
| Sega World Tournament Golf |
| seisyun-scandal |
| Sensible Soccer |
| SF-7000 Initial Program Loader ROM |
| Shadow Dancer |
| Shadow of the Beast |
| Shanghai |
| Shapes and Columns |
| Shinnyushain Tooru Kun |
| Shinobi |
| Shinobi: Part 2 |
| Shooting Gallery |
| Simpsons, The - Bart vs. the Space Mutants |
| Simpsons, The - Bart vs. the World |
| Sindbad Mystery |
| Sitio do Picapau Amarelo |
| Slap Shot |
| Smurfs Travel the World, The |
| Smurfs, The |
| Solomon no Kagi - Oujo Rihita no Namida |
| Sonic Blast |
| Sonic Boy 4 - Monster World |
| Sonic Chaos |
| Sonic Spinball |
| Sonic The Hedgehog |
| Sonic The Hedgehog 2 |
| Sonic-Boy 2 - Eggman's Trap |
| Sonic-Boy 3 - Eggman's Room |
| Sonic-Boy in Monster Land |
| Soukoban |
| Space Harrier |
| Space Harrier 3D |
| Space Invaders |
| Space Mountain |
| Space Slalom |
| Spacegun |
| Special Criminal Investigation |
| Special Promotion M.System III Compact |
| Speedball |
| Speedball 2 |
| Spellcaster |
| Spider-Man - Return of the Sinister Six |
| Spider-Man vs. the Kingpin |
| Sports Pad Football |
| Spy vs. Spy |
| Star Force |
| Star Jacker |
| Star Wars |
| Street Fighter 2 |
| Streets of Rage |
| Streets of Rage 2 |
| Strider |
| Strider II |
| Submarine Attack |
| Sukeban Deka 2 |
| Summer Games |
| Super Basketball |
| Super Jeux Yeno Examples |
| Super Kick Off |
| Super Monaco GP |
| Super Off-Road |
| Super Racing |
| Super Smash TV |
| Super Space Invaders |
| Super Tank |
| Super Tennis |
| Super Wonder Boy |
| Super Wonder Boy - Monster World |
| Superman |
| Sword Cross Warrior |
| System BIOS |
