| S.S. Lucifer - Man Overboard! |
| Samurai Shodown |
| Scratch Golf |
| SD Gundam - Winner's History |
| Sega Game Pack 4 in 1 |
| Sensible Soccer |
| Shadam Crusader: Harukanaru Oukoku |
| Shadam Crusader: Harukanaru Oukoku |
| Shanghai II |
| Shaq Fu |
| Shikinjou |
| Shining Force Gaiden |
| Shining Force Gaiden - Final Conflict |
| Shining Force II - The Sword of Hajya |
| Shinobi II - The Silent Fury |
| Side Pocket |
| Simpsons, The - Bart vs. The Space Mutants |
| Simpsons, The - Bart vs. The World |
| Simpsons, The - Bartman Meets Radioactive Man |
| Simpsons, The - Krusty's Fun House |
| Sisters - Of Light and Darkness |
| Slider |
| Smurfs, The |
| Solitaire Funpak |
| Solitaire Poker |
| Sonic Blast |
| Sonic Chaos |
| Sonic Drift |
| Sonic Drift 2 |
| Sonic Labyrinth |
| Sonic Spinball |
| Sonic The Hedgehog |
| Sonic The Hedgehog - Triple Trouble |
| Sonic The Hedgehog 2 |
| Soukoban |
| Space Harrier |
| Spider-Man - Return of the Sinister Six |
| Spider-Man and the X-Men in Arcade's Revenge |
| Spider-Man vs. The Kingpin |
| Sports Illustrated Championship Football & Baseball |
| Sports Trivia |
| Sports Trivia - Championship Edition |
| Star Trek Generations - Beyond the Nexus |
| Star Trek TNG - Advanced Holodeck Tutorial |
| Star Wars |
| Stargate |
| Street Fighter |
| Streets of Rage |
| Streets of Rage II |
| Strider Returns |
| Super Battletank |
| Super Columns |
| Super Golf |
| Super Kick Off |
| Super Monaco GP |
| Super Off-Road |
| Super Return of the Jedi |
| Super Smash T.V. |
| Super Space Invaders |
| Super Tetris |
| Superman |
| Surf Ninjas |
| Sylvan Tale |
